Abstract #0436

Increased Local Connectivity in Children with ADHD

Suresh Emmanuel Joel^1,2, Priti Srinivasan³, Simona Spinelli,^3,4, Stewart H. Mostofsky,^3,4, James J. Pekar^1,2

¹Radiology, Johns Hopkins University, Baltimore, MD, United States; ²FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; ³Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, United States; ⁴Neurology, Johns Hopkins University, Baltimore, MD, United States

Resting state functional connectivity MRI performed on neurotypical children and children with attention deficit hyperactivity disorder (ADHD), revealed increased local connectivity of pre-supplementary motor area (an important atypically behaving neural substrate in rapid motor response inhibition tasks in ADHD) and increased local connectivity of the precunues (a locus of the default mode network) in children with ADHD. Local connectivity has been previously shown to decrease with age in TD children. Our results suggest a delay in this typical maturation process in children with ADHD.