Abstract #0439

Resting State Functional Connectivity in Patients with Periodic Hypersomnia

Maria Engstrm¹, Thomas Karlsson², Anne-Marie Landtblom³

¹IMH/Radiological Sciences/CMIV, Linkping University, Linkping, Sweden; ²Behavioural Sciences and Learning/CMIV, Linkping University, Linkping, Sweden; ³IKE/Neurology/CMIV, Linkping University, Linkping, Sweden

Functional connectivity of intrisic fluctuations in the resting brain was investigated in order to scrutinize the neuropathology of patients with periodic hypersomnia, Kleine-Levin syndrome (KLS). The main findings were that KLS patients exhibited increased coupling in the middle and inferior frontal gyri (Brocas area) and decreased coupling in the left superior temporal gyrus (Wernickes area) as compared to healthy controls. In a previous study we showed working memory dysfunction accompanied by thalamic and left prefrontal hypoactivity in KLS. These findings suggest aberrant function in the thalamo-cortical networks, which might explain the patients symptoms.