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Abstract #0442

Vascular Alterations and Recruitment in Spinal Cord Injury Revealed by Multislice Arterial Spin Labeling (ASL) Perfusion Imaging

Guillaume Duhamel1, Tanguy Marqueste2, Michal Sdika1, Mohamed Tachrount1, Patrick Decherchi2, Patrick J. Cozzone1, Virginie Callot1

1CRMBM / CNRS 6612, Facult de Mdecine, Universit de la Mditerrane, Marseille, France; 2ISM, Universit de la Mditerrane, Marseille, France

The combination of diffusion tensor imaging (DTI) and perfusion imaging has the potential to be a useful tool in spinal cord injury (SCI) investigation. Assessment of mouse SC blood flow (SCBF), recently demonstrated to be feasible by flow-sensitive alternating inversion recovery arterial spin labeling (FAIR-ASL), was based on single slice technique. However, multislice perfusion imaging matching DTI acquisitions would be required for lesion characterization. We then modified the original FAIR sequence to a FAIR-QUIPPSSII sequence, multislice compatible and optimized to mouse SC, and applied it along with DTI in a follow-up study performed over time on mice having received SCI.