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Abstract #0443

Quantification of Spinal Cord Blood Volume in Humans Using VASO MRI

Jinsoo Uh1, Yan Cao2, Hanzhang Lu1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Mathematical Sciences, University of Texas at Dallas, Dallas, TX, United States

We have developed a technique based on Vascular-Space-Occupancy (VASO) MRI to measure spinal cord blood volume. The VASO sequence has been carefully adjusted to deal with the challenging aspects in imaging spinal cord such as small dimensions, tissue inhomogeneities, and cord motions. We compared two VASO protocol schemes and the one using multiple spin echoes showed better performance. The scBV values with this protocol were 1.80.2 ml/100 ml tissue for gray matter and 1.10.1 for white matter. To our knowledge, this is the first report of blood volume in gray and white matters of human spinal cord.