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Abstract #0444

Rapid Three-Dimensional Myelin Water Fraction Imaging of the Cervical Spinal Cord

Shannon Kolind1,2, Sean Deoni2

1FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2Centre for Neuroimaging Sciences, King's College London, London, United Kingdom

The pathology of myelin in spinal cord disease is poorly understood due to the technical challenges of measuring myelin noninvasively. Our goal was to assess the efficacy of multi-component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) for obtaining high spatial resolution spinal cord myelin water fraction (MWF) data covering the entire cervical spinal cord. Our results demonstrated the ability to reliably acquire high quality MWF data, at a spatial resolution of 1x1x1.5mm over a 12x12x18cm field-of-view, with MWF values consistent with prior literature values and a coefficient of variation of less than 3%.