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Abstract #0461

Optimization of Liposomal Theragnosis: Quantitative T1 Measurement of Drug Distribution and Release in Deep-Seated Tumor Using Multimodal Thermo-Sensitive Polymer-Modified Liposome

Daisuke Kokuryo1, Seiji Nakashima2, Kai-Hsiang Chuang3, Iwao Kanno1, Kenji Kono2, Ichio Aoki1

1Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; 2Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka, Japan; 3Singapore Bioimaging Consortium, Singapore, Singapore

A multimodal thermo-sensitive polymer-modified liposome (MTPL) loaded with anticancer drugs and contrast agents would be a powerful 'Theragnostic (therapy + diagnosis)' tool. In this paper, drug concentration in deep-seated tumor was evaluated using MTPL and a rapid quantitative imaging technique. Heat-triggered drug-release from MTPL was visualized in combination with the temperature distribution. MTPL concentration in the tumor area was maintained for between 4 and 12 hours after administration. We concluded that to minimize side-effects the optimum time to apply a heat-trigger is 12 - 24 hours after MTPL administration.