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Abstract #0462

Magnetic Resonance Microscopic Angiography Visualization of Abnormal Microvasculature in a Transgenic Mouse Model of Huntingtons Disease

Chien-Yuan Lin1, Chien-Hsiang Huang1,2, Ming-Huang Lin1, Yi-Hua Hsu1, Chung-Ru Tsai1, Hui-Mei Chen1, Yijuang Chern1, Chen Chang1

1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan

The underlying mechanisms of neurodegenerative disease are still unclear. However, the cerebral microcirculation may play an important role. This study aimed to explore the microvasculature in a transgenic mouse model of Huntingtons disease using newly developed microscopy MRA.