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Abstract #0463

Longitudinal Changes in the Neurochemical Profile of Hungtington R6/2 Mice

Ivan Tkac1, Lori A. Zacharoff2, Silvia Mangia1, Patrick J. Bolan1, Janet M. Dubinsky2

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Dept. of Neuroscience, University of Minnesota, Minneapolis, MN, United States

In vivo 1H NMR spectroscopy at 9.4T was used to measure neurochemical changes in striatum and cerebral cortex of R6/2 transgenic mice during their lifespan, starting from a presymptomatic age of 4 weeks. Significant differences were observed for multiple brain metabolites between R6/2 and WT controls. Concentration changes in cortex were parallel to those observed in striatum. Changes in the neurochemical profiles correlated with reduced volumes of these brain regions. Behavioral differences were observed at all time points, although different tests distinguished R6/2 mice from WT controls at early and older ages.