Stephen J. Sawiak1,2, Nigel I. Wood3,
Guy B. Williams1, A J. Morton3, T A. Carpenter1
1Wolfson Brain Imaging Centre,
University of Cambridge, Cambridge, Cambs, United Kingdom; 2Behavioural
and Clinical Neurosciences Institute, University of Cambridge, Cambridge,
United Kingdom; 3Department of Pharmacology, University of
Cambridge, United Kingdom
We
present an improved method of cortical thickness measurement in the mouse
brain and apply it to 116 brains in the R6/2 mouse model of Huntington's
disease. Significant changes are seen in the sensorimotor cortices (S1, S2,
M1) which would be expected in a HD model. Cingulate cortex (Cg1, Cg2)
differences are also shown which have not been previously reported in these
mice.