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Abstract #0464

Cingulate and Sensorimotor Cortical Changes in the R6/2 Huntington's Disease Mouse: A Study of 116 Brains

Stephen J. Sawiak1,2, Nigel I. Wood3, Guy B. Williams1, A J. Morton3, T A. Carpenter1

1Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, Cambs, United Kingdom; 2Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom; 3Department of Pharmacology, University of Cambridge, United Kingdom

We present an improved method of cortical thickness measurement in the mouse brain and apply it to 116 brains in the R6/2 mouse model of Huntington's disease. Significant changes are seen in the sensorimotor cortices (S1, S2, M1) which would be expected in a HD model. Cingulate cortex (Cg1, Cg2) differences are also shown which have not been previously reported in these mice.