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Abstract #0474

3D Proton MR Spectroscopic Imaging of Prostate Cancer: Accuracy Evaluation in Different Prostate Regions

Stefan Zbyn1,2, Martin Krssak2, Mazda Memarsadeghi2, Klaus Kubin2, Andrea Haitel3, Michael Weber2, Thomas Helbich2, Ewald Moser1, Siegfried Trattnig1,2, Stephan Gruber1,2

1MR Centre of Excellence, Medical University of Vienna, Vienna, Austria; 2Department of Radiology, Medical University of Vienna, Vienna, Austria; 3Department of Pathology, Medical University of Vienna, Vienna, Austria

Since spectral quality of prostate 3D-MRSI data vary dramatically within measured volume, the total inaccuracies in (choline+creatine)/citrate (CC/C) ratios using Cramr-Rao lower bounds were calculated to compare the accuracy of this method between different prostate regions and measurement resolutions. Our analysis suggests that voxels from prostate base and from periphery of the prostate suffer the most from inaccurate CC/C ratios. To prevent from misleading findings or time consuming manual inspection of spectral quality in each prostate voxel, the metabolic-quality maps, that combine the information of CC/C ratio and its accuracy in one image using the various voxel transparencies, are demonstrated.