Masoom Haider1,2, Laurence Klotz3,4,
Michael Bronskill5,6, Kashif Siddiqui3, Alexandra
Colquhoun3, Linda Sugar7, Rajiv Chopra5,6
1Medical Imaging, Sunnybrook Health
Sciences Center, Toronto, Ontario, Canada; 2Medical Imaging,
University of Toronto, Toronto, Ontario, Canada; 3Urology,
Sunnybrook Health Sciences Center, Toronto, Ontario, Canada; 4Surgery,
University of Toronto, Toronto, Ontario, Canada; 5Imaging
Research, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada; 6Medical
Biophysics, University of Toronto, Toronto, Ontario, Canada; 7Pathology,
Sunnybrook Health Sciences Center, Toronto, Ontario, Canada
MRI-guided
transurethral ultrasound therapy with real-time thermometry feedback has the
potential to reduce morbidity of prostate cancer therapy. To our knowledge
this is the first report of the use of this technology in humans. The
procedure was performed immediately prior to prostatectomy. Ultrasound energy
was delivered while MR thermography was performed. The rate of rotation and
output power of the applicator were adjusted by computer control. Treatment
times were 9-10 minutes. The maximum temperature distribution map 55C
boundary matched the histologic section showing necrosis. It is feasible to perform
accurate spatial heating of the prostate in humans using MRI-guided
transurethral ultrasound.