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Abstract #0476

Wash-Out Gradient Derived from Dynamic Contrast-Enhanced MRI Detects Cancerous Tissues and Predicts Gleason Scores in Prostate Cancer

Yu-Jen Chen1, Woei-Chyn Chu1, W-Y Isaac Tseng2,3

1Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan; 2Departments of Medical Imaging National Taiwan University Hospital, Taipei, Taiwan; 3Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan

DCE MRI was reported to assess microvascularity of prostate cancer, and is potentially useful to predict clinical staging. However, there are few studies demonstrating weak association between DCE MRI parameters and Gleason score. In this study, we have retrospectively analyzed the DCE MRI parameters in pathologically confirmed PCA regions. We found that washout gradient values were capable of differentiating PCA from normal tissues and best correlated with Gleason score.