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Abstract #0477

Validation of Multiparametric Magnetic Resonance Imaging and Spectroscopy (DWI/MRSI) to Assess Prostate Cancer Aggressiveness

Thiele Kobus1, Thomas Hambrock1, Christina Hulsbergen - Van de Kaa2, Jelle Barentsz1, Arend Heerschap1, Tom Scheenen1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

To validate the use of diffusion weighed imaging (DWI) and magnetic resonance spectroscopic imaging (MRSI) for tumor aggressiveness assessment, 37 patients with prostate cancer had a magnetic resonance imaging, DWI and MRSI exam on a 3T system with endorectal coil prior to prostatectomy. Individual and combined DWI and MRSI methods were used to discriminate between high- and low-grade tumors using histopathology as gold standard. Combining DWI and MRSI with linear discriminant analysis to separate tumors gave a higher sensitivity and specificity than any of the techniques separately. This suggests that DWI and MRSI provide complementary information about aggressiveness.