Jie Zheng1, Donna Lesniak2, Robert O'Connor, David Muccigrosso, Linda Peterson, Chris Eagon, Pamela K. Woodard, Robert J. Gropler
1Radiology, Washington University in St. Louis, Saint Louis, MO, United States; 2Radiology, Washington University in St. Louis, United States
Obese patients underwent gastric bypass surgery and then scanning by positron emission tomography for cardiac evaluation, including perfusion and oxygen consumption. A cardiac MR acquisition method and modeling were developed to quantify global myocardial oxygen extraction fraction and oxygen consumption in these patients and BMI matched volunteers, at rest and during the hyperemia Excellent correlation was observed for oxygen extraction fraction and consumption rate between MRI and PET. Mismatched myocardial blood flow and hyperemic OEF, observed in obesity, indicates metabolism alternation may precede myocardial microcirculation abnormality in obese.