Jie Zheng1, Donna Lesniak2,
Robert O'Connor, David Muccigrosso, Linda Peterson, Chris Eagon, Pamela K.
Woodard, Robert J. Gropler
1Radiology, Washington University in
St. Louis, Saint Louis, MO, United States; 2Radiology, Washington
University in St. Louis, United States
Obese
patients underwent gastric bypass surgery and then scanning by positron
emission tomography for cardiac evaluation, including perfusion and oxygen
consumption. A cardiac MR acquisition method and modeling were developed to
quantify global myocardial oxygen extraction fraction and oxygen consumption
in these patients and BMI matched volunteers, at rest and during the
hyperemia Excellent correlation was observed for oxygen extraction fraction
and consumption rate between MRI and PET. Mismatched myocardial blood flow
and hyperemic OEF, observed in obesity, indicates metabolism alternation may
precede myocardial microcirculation abnormality in obese.
Keywords