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Abstract #0485

Free-Breathing Perfusion Imaging with SW-CG-HYPR and Motion Correction

Lan Ge1, Aya Kino1, Mark Griswold2, James Carr1, Debiao Li1

1Departments of Radiology and Biomedical Engineering, Northwestern University, Chicago, IL, United States; 2Departments of Radiology and Biomedical Engineering, Case Western Reserve University, OH, United States

Time-resolved data acquisition with Sliding-Window Conjugate-Gradient HighlY constrained back PRojection (1, 2) (SW-CG-HYPR) has been used to acquire myocardial perfusion images with increased spatial coverage, better spatial resolution, and improved SNR (3). However, this method is sensitive to respiratory motion; therefore, breath-hold is required during data acquisition. In this work, we developed a motion correction method for SW-CG-HYPR, allowing free-breathing myocardial perfusion MRI. The average image quality score of the free-breathing images with motion correction (3.090.37) is significantly higher than that without motion correction (2.260.40), and is comparable to the successful breath-holding images (3.100.41). The signal changes in motion corrected free-breathing images were closely correlated to the breath-holding images, with a correlation coefficient of 0.9764 for myocardial signals.