Frans PPJ Kremers1, Jan GJ Groothuis2, Aernout M. Beek2, Stijn L. Brinckman2, Alvin C. Tuinenburg2, Michael Jerosch-Herold3, Albert C. van Rossum2, Mark B.M. Hofman1
1Physics and Medical Technology, ICaR-VU, VU University Medical Center, Amsterdam, Netherlands; 2Cardiology, ICaR-VU, VU University Medical Center, Amsterdam, Netherlands; 3Radiology, Brigham & Women's Hospital, Boston, MA, United States
Dual-bolus first pass MR myocardial perfusion imaging has been shown to compensate for signal saturation in arterial input function, and resulted into more realistic perfusion values. We investigated whether this dual bolus approach also improved diagnostic value for the detection of significant coronary artery disease (CAD). In 49 patients with suspected CAD adenosine stress and rest MR perfusion imaging was performed with single and dual bolus imaging. Invasive coronary angiography was used as standard of reference. Dual bolus imaging showed lower perfusion values, but ROC analysis showed no incremental diagnostic value over single bolus technique for detection of significant CAD.