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Abstract #0510

Is Reduced CBV a Reliable Surrogate Marker for Infarct Core and Can It Be Used to Identify Lesion Mismatch?

Matus Straka1, Jun Lee2, Maarten G. Lansberg2, Michael Mlynash2, Gregory W. Albers2, Roland Bammer1

1Radiology, Stanford University, Stanford, CA, United States; 2Stroke Center, Stanford University Medical Center, Stanford, CA, United States

Mismatch between stroke core and penumbra can be used used to identify patients that could benefit from reperfusion therapies. Hyperintense DWI in MRI or hypointense CBV in CT can be used to identify stroke core, and equivalence of CT-CBV and DWI lesion volumes was tested. DSC-MRI CBV was used as a surrogate for CT-CBV and 59 patients were analyzed. Results indicate that only large lesions (>10ml) can be identified on CBV and accuracy and reliability of CBV-based mismatch is lower then of DWI. CBV-based stroke core identification yeilded generally smaller lesions and correlation with DWI was low.