Abstract #0509

Quantitative MR Perfusion and Ischemic Stroke: Improved Discrimination Between Ischemic and Presumed Penumbra Using QCBF Over Tmax or MTT

Christopher S. Eddleman¹, Maulin Shah², Omar M. Arnaout¹, Richard Bernstein³, Bernard R. Bendok¹, Hunt H. Batjer¹, Timothy J. Carroll⁴

¹Neurological Surgery, Northwestern University, Chicago, IL, United States; ²Biomedical Engineering, Pennsylvania State University, State College, PA, United States; ³Neurology, Northwestern University, Chicago, IL, United States; ⁴Radiology, Northwestern University, Chicago, IL, United States

Time-based indicators of cerebral blood flow, e.g., Tmax and MTT, are often used to grade stroke severity in both MR and CT perfusion studies. However, these measures often overestimate the infarcted territory, thus underestimating salvagable brain. We show that quantitative MR perfusion is superior to time-based measures in distinguishing normally perfused from ischemic brain tissue.