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Abstract #0567

Imaging of Blood Flow Using Hyperpolarized 13C-Urea in Preclinical Murine Models

Cornelius von Morze1, Peder E. Larson1, Simon Hu1, Kayvan Keshari1, David M. Wilson1, Jan Henrik Ardenkjaer-Larsen2, John Kurhanewicz1, Daniel B. Vigneron1

1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2GE Healthcare, Hillerd, Denmark

We demonstrate regional imaging of blood flow in preclinical murine models with hyperpolarized (DNP) 13C-urea. A bSSFP pulse sequence was developed, with progressively increasing flip angles for efficient sampling of the hyperpolarized magnetization. This allowed temporal and volumetric imaging at a spatial resolution of 2.5mm x 2.5mm x 8mm with a time resolution of 6 s. Regional signal dynamics were quantified, and estimates of relative blood flow to the kidneys and the liver were made. Differences were observed in blood flow patterns to normal and cancerous hepatic tissues. The blood flow maps were compared to results of metabolic maps of 1-13C-pyruvate.