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Abstract #0586

Balanced Steady-State Free Precession Magnetic Resonance Images Edema in Acute Reperfused Myocardial Infarction a Translational Study in Animals and Humans

Andreas Kumar1, Nirat Beohar2, Jain Mangalathu Arumana3, Debiao Li3, Matthias G. Friedrich1, Rohan Dharmakumar3

1Stephenson CMR Centre, University of Calgary, Calgary, AB, Canada; 2Dept. of Cardiology , Northwestern University, Chicago, IL, United States; 3Dept. of Radiology, Northwestern University, Chicago, IL, United States

We assessed the role of balanced steady-state free precession magnetic resonance for imaging of myocardial edema in acute reperfused myocardial infarction. In an experimental animal model as well as in patients with ST-elevation myocardial infarction, we found a close correlation of hyperintense b-SSFP signal areas with T2-STIR as a reference standard. Contrast-to-noise was not different between both sequences, and the area of b-SSFP hyperintensity was consistently larger than the area of irreversible injury on late contrast enhancement, consistent with b-SSFP reflecting the area-at-risk in acute ischemia-reperfusion injury. B-SSFP may evolve as a novel approach for myocardial edema imaging.