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Abstract #0593

4T 7Li MRSI in the Brains of Bipolar Disorder Subjects

Jing-Huei Lee1,2, Matthew M. Norris1, Caleb M. Adler, 2,3, Elizabeth E. Macaluso2, Wen-Jang Chu, 2,3, Richard A. Komoroski, 2,3, Stephen M. Strakowski, 2,3

1Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States; 2Center for Imaging Research, University of Cincinnati, Cincinnati, OH, United States; 3Psychiatry, University of Cincinnati, United States

This work proposes and compares two approaches for 7Li MRSI data analysis: Method I: 1D-3D vs. Method II: 3D-1D approach. The result shows that there is virtually no difference between these two approaches. However, Method I is preferred for use in future data analysis since it is simple in practice. Furthermore, this study is the first demonstration of the 7Li distribution in the brain of bipolar patients who are on lithium therapy. The distribution is not uniform throughout the entire brain for all patients, which is unexpected. Further investigations are ongoing.