Jing-Huei Lee1,2, Matthew M. Norris1,
Caleb M. Adler, 2,3, Elizabeth E. Macaluso2, Wen-Jang
Chu, 2,3, Richard A. Komoroski, 2,3, Stephen M.
Strakowski, 2,3
1Biomedical Engineering, University of
Cincinnati, Cincinnati, OH, United States; 2Center for Imaging
Research, University of Cincinnati, Cincinnati, OH, United States; 3Psychiatry,
University of Cincinnati, United States
This
work proposes and compares two approaches for 7Li MRSI data
analysis: Method I: 1D-3D vs. Method II: 3D-1D approach. The result shows
that there is virtually no difference between these two approaches. However,
Method I is preferred for use in future data analysis since it is simple in
practice. Furthermore, this study is the first demonstration of the 7Li
distribution in the brain of bipolar patients who are on lithium therapy. The
distribution is not uniform throughout the entire brain for all patients,
which is unexpected. Further investigations are ongoing.
Keywords