Jonathan Dudley1, Wen-Jang Chu2,3,
Xin Wang1, Matt Norris1, Jing-Huei Lee1,3
1Biomedical Engineering, University of
Cincinnati, Cincinnati, OH, United States; 2Psychiatry, University
of Cincinnati, Cincinnati, OH, United States; 3Center for Imaging
Research, University of Cincinnati, Cincinnati, OH, United States
The
theory of mitochondrial dysfunction in bipolar disorder (BD) has been
supported by numerous MRS studies.
However, the absolute quantitation of phosphor metabolites in this
disease has not been well studied.
This work is to determine phosphor metabolite concentrations in the
anterior cingulate cortex among different subject groups. The results were in concordance with the
theory of mitochondrial dysfunction, showing a decrease in intracellular pH
and [ADP] in manic and mixed BD patients relative to controls.