Ulrike Dydak1,2, Jonathan M. Nixon1, Mario Dzemidzic3, Harish Sai Karne4, Amit Anand4
1School of Health Sciences, Purdue University, West Lafayette, IN, United States; 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States; 3Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States; 4Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States
Changes in brain metabolism were studied in medication-free patients with bipolar and unipolar disorder and compared to matched healthy controls. 2D MRSI data acquired in an axial slice including thalamus, anterior and posterior cingulate cortex (ACC & PCC) were analyzed using LCModel. Significant decreases in NAA/ creatine were found in bipolar patients compared to healthy controls in the right thalamus and right ACC. Furthermore, when comparing bipolar to unipolar patients, significant decreases in the choline/creatine ratio were observed in the right thalamus. No significant group differences were found in the PCC nor any of the left hemisphere regions of interest.