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Abstract #0596

Dissociation of Anterior Cingulate Glutamate and Induced Theta EEG Activity in Schizophrenia.

Antonio Napolitano1, Kathrin Doege2, Mallikarjun Pavan2, Peter Liddle2, Dorothee P. Auer1

1Academic Radiology, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Division of Psychiatry, University of Nottingham, United Kingdom

The glutamate hypothesis stimulated over the last two decades several MRS studies to research alterations of glutamate levels in schizophrenia. In this study, we used a combined EEG/MRS protocol to investigate whether prefrontal glutamate levels are altered in patients with early schizophrenia and whether there is an interrelation between glutamate and theta activity in schizophrenia.