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Abstract #0598

1H MRS Measurement of Brain Glutathione Supports Increased Oxidative Stress in Major Depressive Disorder

Sanjay J. Mathew1, Xiangling Mao2, Sarah Pillemer1, James W. Murrough1, Dikoma C. Shungu2

1Psychiatry, Mount Sinai School of Medicine, New York, NY, United States; 2Radiology, Weill Cornell Medical College, New York, NY, United States

A large body of anecdotal evidence now implicates increased oxidative stress in a number of pathophysiologic models of major depressive disorder (MDD). In this study, the first in vivo 1H MRS measurements of the primary cellular antioxidant glutathione (GSH) were made in the occipital lobe of MDD patients and found to be significantly decreased compared to healthy control subjects, which supports the presence of increased oxidative stress in the disorder.