Sanjay J. Mathew1, Xiangling Mao2,
Sarah Pillemer1, James W. Murrough1, Dikoma C. Shungu2
1Psychiatry, Mount Sinai School of
Medicine, New York, NY, United States; 2Radiology, Weill Cornell
Medical College, New York, NY, United States
A
large body of anecdotal evidence now implicates increased oxidative stress in
a number of pathophysiologic models of major depressive disorder (MDD). In
this study, the first in vivo 1H
MRS measurements of the primary cellular antioxidant glutathione (GSH) were
made in the occipital lobe of MDD patients and found to be significantly
decreased compared to healthy control subjects, which supports the presence
of increased oxidative stress in the disorder.