Jeffrey A. Stanley1, Dalal Khatib1, Rachel M. Dick1, Olivia A. McGarragle1, Frank P. MacMaster1, Vaibhav A. Diwadkar1, Arthur L. Robin1, David R. Rosenberg1
1Psychiatry and Behavioral
Attention Deficit Hyperactivity Disorder (ADHD) is a serious public health problem that affects between 3 to 9% of children and accounts for between 30 to 40% of child referrals to mental health services. While the cause of this illness remains poorly understood, ADHD is increasingly seen as a neurodevelopmental disorder. In vivo 31P spectroscopy is a neuroimaging method that is sensitive in detecting biochemical changes as the brain develops. The purpose of this study is to provide further evidence of a developmental mechanism where early maldeveloped corticostriatal pathways may impact the maturational integration of prefrontal corticostriatal pathways in pediatric ADHD.