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Abstract #0599

Evidence of Age Effects in Cortical Areas But Not in the Subcortex of ADHD Children: A Multi-Voxel In Vivo 31P Spectroscopy Study at 4 Tesla

Jeffrey A. Stanley1, Dalal Khatib1, Rachel M. Dick1, Olivia A. McGarragle1, Frank P. MacMaster1, Vaibhav A. Diwadkar1, Arthur L. Robin1, David R. Rosenberg1

1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States

Attention Deficit Hyperactivity Disorder (ADHD) is a serious public health problem that affects between 3 to 9% of children and accounts for between 30 to 40% of child referrals to mental health services. While the cause of this illness remains poorly understood, ADHD is increasingly seen as a neurodevelopmental disorder. In vivo 31P spectroscopy is a neuroimaging method that is sensitive in detecting biochemical changes as the brain develops. The purpose of this study is to provide further evidence of a developmental mechanism where early maldeveloped corticostriatal pathways may impact the maturational integration of prefrontal corticostriatal pathways in pediatric ADHD.