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Abstract #0600

Disruption of Commissural White Matter Tracts in Pediatric Bipolar Disorder

Hao Huang1, Kirti Saxena2, Annie Walley2, Min Xu1, Nancy Rollins3

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States


Identifying early signs of bipolar disorder is important because it may enable health care providers to intervene earlier and prevent progression of increased morbidity and personal dysfunction. Commissural tracts including corpus callosum (CC) and anterior commissure (AC) are the research target in this study. In our study, we acquired high resolution DTI from 10 pediatric bipolar patients and 10 age matched control subjects. We found that AC and anterior segment of CC has statistically smaller FA. Compared to DTI results of adult BP, the disruption pattern caused by BP demonstrates anterior to posterior pattern from childhood to adult.