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Abstract #0601

Atypical Development of White Matter Microstructure in Adolescents with Autism Spectrum Disorders

Kun-Hsien Chou1, I-Yun Chen2, Ya-Wei Cheng2, Jean Decety3, Yang-Teng Fan2, Ching-Po Lin2,4

1Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan; 2Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan; 3Departments of Psychology and Psychiatry, The University of Chicago, Chicago, United States; 4Institute of Biomedical imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

Autism spectrum disorders is a common brain developmental disorder that occurs in one in 150 children. It is characterized by early onset of impaired social reciprocity and communication difficulties, along with restricted interest and stereotyped behavior. Several brain morphometry studies suggested that cascade failure of neurodevelopment is the most likely the core deficit of ASD. But whether aberrant WM development persisted into later childhood and adolescence was a crucial issue to probe. The aim of the present study was to examine WM microstructure using diffusion tensor imaging (DTI) and to investigate its relations to age in adolescents with ASD.