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Abstract #0602

MR Elastography and MRI Volumetry of the Aging Brain

Kaspar Josche Streitberger1, Dagmar Krefting2, Friedemann Paul3, Dieter Klatt1, Sebastian Papazoglou1, Sebastian Hirsch1, Jrgen Braun2, Ingolf Sack1

1Institute of Radiology, Charit - University Medicine Berlin, Berlin, Germany; 2Institute of Medical Informatics, Charit - University Medicine Berlin, Berlin, Germany; 3Neurocure, Charit - University Medicine Berlin, Berlin, Germany

Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties, which are characterized by mechanical parameters such as stiffness and internal friction. To date Magnetic Resonance Elastography (MRE) is the only non-invasive technique for measuring the shear viscoelastic properties of living brain. This study compares the decrease of brain stiffness with years of age in normal volunteers observed by MRE with loss of brain volume found by MRI volumetry.