Efrat Sasson1, Glen M. Doniger2,
Ofer Pasternak3, Tal Gonen4, Yaniv Assaf5
1Neurobiology department, Tel Aviv
University, Tel Aviv, Israel; 2Department of Clinical Science,
NeuroTrax Corporation, Newark, NJ, United States; 3Brigham and
Women's Hospital, Harvard Medical School, Boston, MA, United States; 4Psychology
department, Tel Aviv University, Tel Aviv , Israel; 5Neurobiology
department, Tel Aviv University, Tel Aviv , Israel
In
this study we used the inter-subject variability in different cognitive
domains to relate cognitive performance and WM integrity in five temporal
projections: the uncinate fasciculus, fornix, cingulum, inferior longitudinal
fasciculus, and superior longitudinal fasciculus. Subjects were 51 healthy
volunteers, 25-80 years, completed cognitive tests and were scanned using DTI
and DTI tractography was performed. The fibers exhibiting substantial
correlation with cognitive performance are known to play an important part in
the corresponding functional domain. Using the methodology performed here,
DTI tractography enables anatomical definition of region of interest for
correlation analysis of any behavioral parameters with diffusion indices.