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Abstract #0606

DTI, T2 Relaxation and Volumetry of the Human Brain Corpus Striatum Across the Lifespan

Khader M. Hasan1, Indika S. Walimuni1, Humaira Abid1, Larry A. Kramer1, Richard E. Frye2, Jack M. Fletcher3, Linda Ewing-Cobbs2

1Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States; 2Pediatrics, UTHSC, Houston, TX, United States; 3Psychology, University of Houston, Houston, TX, United States

In this work, we report for the first time a comprehensive account of the macro and microstructure of these structures using a large cross-sectional healthy cohort across the healthy lifespan (N=281 males and females aged 6-68 years). We demonstrate using a validated novel DTI and atlas-based tissue segmentation approach that the MRI microstructural correlates of volume decrease of these structures bilaterally, in both men and women are a T2 relaxation that follows a U curve that is commensurate with a fractional ansiotropy increases with age and a U curve mean diffusivity. A strong correlation between T2 and mean, radial and axial diffusivities is also noted. The interplay between T2 relaxation and DTI metrics was also examined.