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Abstract #0615

Correlation of Metabolic Characteristics with Diffusion Tensor Imaging in Human Gliomas

Greg A. Fellows1, Alan J. Wright2, Tom R. Barrick3, Dominick J O McIntyre4, Chris A. Clark5, B Anthony Bell6, Franklyn A. Howe7

1Department of Neurosurgery, King's College Hospital London NHS Trust, London, United Kingdom; 2Radiology, UMC st. Radboud University Hospital, Nijmegen, Netherlands; 3Clinical Neuroscience, St George's, University of London, London, United Kingdom; 4CRUK Cambridge Research Institute, Cambridge, United Kingdom; 5Radiology and Physics Unit, UCL Institute of Child Health, London, United Kingdom; 6Academic Neurosurgery, St George's, University of London, London, United Kingdom; 7Cardiac & Vascular Sciences, St George's, University of London, London, United Kingdom

Gliomas are the most common primary brain tumour, and in their most aggressive form, glioblastoma multiforme, are associated with a mean survival of 9-12 months. Despite maximal therapy, nearly all gliomas eventually recur. The majority of this recurrence is at the limits of previous resection / radiotherapy margins. We have combined 1H spectroscopy metabolite maps and DTI structural metrics of 30 histologically confirmed glioma patients to increase our understanding of the tissue changes that occur within the tumour and at the tumour-brain interface. We identify metabolite correlations with DTI metrics as a surrogate marker for tumour infiltration.