Greg A. Fellows1, Alan J. Wright2,
Tom R. Barrick3, Dominick J O McIntyre4, Chris A. Clark5,
B Anthony Bell6, Franklyn A. Howe7
1Department of Neurosurgery, King's College
Hospital London NHS Trust, London, United Kingdom; 2Radiology, UMC
st. Radboud University Hospital, Nijmegen, Netherlands; 3Clinical
Neuroscience, St George's, University of London, London, United Kingdom; 4CRUK
Cambridge Research Institute, Cambridge, United Kingdom; 5Radiology
and Physics Unit, UCL Institute of Child Health, London, United Kingdom; 6Academic
Neurosurgery, St George's, University of London, London, United Kingdom; 7Cardiac
& Vascular Sciences, St George's, University of London, London, United
Kingdom
Gliomas
are the most common primary brain tumour, and in their most aggressive form,
glioblastoma multiforme, are associated with a mean survival of 9-12
months. Despite maximal therapy,
nearly all gliomas eventually recur.
The majority of this recurrence is at the limits of previous resection
/ radiotherapy margins. We have
combined 1H spectroscopy metabolite maps and DTI structural metrics of 30
histologically confirmed glioma patients to increase our understanding of the
tissue changes that occur within the tumour and at the tumour-brain
interface. We identify metabolite
correlations with DTI metrics as a surrogate marker for tumour infiltration.
Keywords