An Image Similarity-Guided Correspondence Correction for Voxel-Wise Analysis Applied to MR Imaging of Glioblastoma Multiforme Acquired Pre- And Post-Chemoradiotherapy

Jeremy David Hoisak^1,2, Eng-Siew Koh^1,3, Eugene Yu⁴, Andrea Kassner⁴, Normand J. Laperriere^1,3, Cynthia Mnard^1,3, David A. Jaffray^1,2

Response assessment with a voxel-wise analysis of serial image change has advantages over conventional tumor measurements, but is susceptible to uncertainties from inconsistent voxel correspondences between scans arising from a dynamic tumor morphology. A correspondence correction method based on a metric of voxel similarity was applied to a functional diffusion map (fDM) analysis of co-registered T1-weighted and diffusion-weighted images of glioblastoma multiforme acquired pre- and post-chemoradiotherapy. The correction resulted in a statistically significant alteration in the quantification of apparent diffusion coefficient (ADC) change pre- and post-therapy, and has the potential to improve the accuracy of subsequent determinations of therapy outcome.