Egbert JW Bleeker1, Matthias JP van Osch1,
Alan Connelly2,3, Mark A. van Buchem1, Andrew G. Webb1,
Fernando Calamante2,3
1C.J.Gorter Center for High Field MRI, Department
of Radiology, Leiden University Medical Center, Leiden, Netherlands; 2Brain
Research Institute, Florey Neuroscience Institutes (Austin), Melbourne,
Australia; 3Department of Medicine, University of Melbourne,
Melbourne, Australia
The
current criteria for AIF selection algorithms determine correct
measurements based on the shape of the first passage. However, this shape can
be altered by partial volume effects, which often occur in AIF measurements
due to the relatively low spatial resolution. A new criterion is proposed,
based on tracer kinetic theory, that uses the additional information of the
steady state to detect partial volume effects in the AIF measurement. This
study shows that the proposed criterion should be a valuable addition to the current
selection criteria.
Keywords