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Abstract #0625

Quantitative Cerebral Perfusion with SCALE-PWI: Accelerated Image Acquisition and Optimized Image Reconstruction

Jessy J. Mouannes1, Wanyong Shin2, Saurabh Shah3, Anindya Sen4, Sameer Maheshwari1, Timothy J. Carroll1,4

1Biomedical Engineering, Northwestern University, Chicago, IL, United States; 2National Institute on Drug Abuse, National Institute of Health, Baltimore, MD, United States; 3Siemens Medical Solutions USA, Chicago, IL, United States; 4Radiology, Northwestern University, Chicago, IL, United States

The multi-scan Bookend technique allows accurate, reliable and reproducible quantitative cerebreal perfusion measurements. An accelerated and simplified version of the Bookend technique protocol has been achieved through a Self-CALibrated Epi Perfusion Weighted Imaging (SCALE-PWI) MRI pulse sequence, with scan time under 2 minutes and allowing inline reconstruction of quantitative images of cerebral perfusion. A study of two different delay times between consecutive modules of SCALE-PWI and a water correction factor (WCF) parameterization for SCALE-PWI are presented at 1.5T. The results show that a fast imaging protocol for SCALE-PWI (with zero delay) with appropriate WCF parameterization provide accurate quantitative cerebral perfusion.