Abstract #0629

Quantitative Assessment of Perfusion and Permeability in Multiple Sclerosis: Feasibility and Initial Results

Michael Ingrisch¹, Steven Sourbron¹, Dominik Morhard, Lisa-Ann Gerdes², Tania Kmpfel², Reinhard Hohlfeld², Maximilian F. Reiser, Christian Glaser

¹Josef Lissner Laboratory for Biomedical Imaging, Institute of Clinical Radiology, Ludwig Maximilian University, Munich, Germany; ²Institute for Clinical Neuroimmunology, Ludwig Maximilian University, Munich, Germany

We evaluate the feasibility of a 3D DCE-MRI measurement for the absolute quantification of perfusion and permeability in Multiple Sclerosis and present initial results. 19 patients were examined, perfusion and permeability were quantified with 2-compartment models in white matter, non-enhancing(NE) and contrast-enhancing(CE) lesions. The results show clear separation of WM and CE lesions in the permeability estimates; WM perfusion was lower than standard values from literature. The parameter variation in NE- and CE-lesions was relatively large, suggesting a potential for lesion characterization and monitoring of the effects of disease-modifiying drugs.