Erik Holt Clayton1, Joel R. Garbow2, Philip V. Bayly1,3
1Mechanical Aerospace & Structural Engineering, Washington University in St. Louis, Saint Louis, MO, United States; 2Biomedical MR Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, United States; 3Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, United States
Multifrequency MR elastography (MRE) has been used to measure mechanical stiffness of human brain tissue. The development of cancer treatment protocols may benefit from similar studies in rodent models. Here the viscoelastic material properties of mouse brain were determined by MRE over a range of driving frequencies (600 - 1800 Hz). A novel non-invasive brain actuator was devised to introduce propagating shear waves. Wave motion was imaged with a phase-locked spin echo pulse sequence. Displacement data were inverted in a least-squares manner to obtain complex modulus estimates. Results suggest the frequency response of brain tissue may provide diagnostic value.