Abstract #0659

Metabolic Profiling of Post-Radiation Prostate Biopsy Tissues

Vickie Yi Zhang^1,2, Mark Swanson¹, Laura Tabatabai³, Jeff Simko³, Lynn DeLosSantos¹, Daniel Vigneron¹, John Kurhanewicz¹

¹Radiology, University of California, San Francisco, San Francisco, CA, United States; ²Joint Bioengineering Program, University of California, Berkeley/San Francisco, San Francisco, CA, United States; ³Pathology, University of California, San Francisco, San Francisco, CA, United States

Synopsis: This study used quantitative 1-D 1H HR-MAS spectroscopy of snap frozen prostate biopsies to investigate the metabolic profiles of healthy versus cancer prostate tissues after radiation therapy. Metabolite concentrations were correlated with pathology and Ki-67 immunohistochemistry to identify a metabolic phenotype of proliferating residue cancer. Significantly higher concentrations of PC+GPC, lactate and glutamate were observed in benign versus residual proliferating cancer tissues after radiation treatment.