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Abstract #0710

Endogenous Opioid-Dopamine Neurotransmission Evokes Sustained Negative CBV-Weighted FMRI Responses

Yen-Yu Ian Shih1,2, Yun-Chen Chiang2,3, Yi-Hua Hsu2, Fu-Shan Jaw3, Jin-Chung Chen4, Bai-Chuang Shyu2, Timothy Q. Duong1, Chen Chang2

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Functional and Micro-Magnetic Resonance Imaging Center, Academia Sinica, Taipei, Taiwan; 3Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 4Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan

Dopamine and opioids have been implicated in various aspects of brain signaling. By employing CBV-weighted fMRI with pharmacological treatments, the present study reveals that endogenous stimulation of ?opioid receptors underlies negative CBV fMRI signals via the activation of dopamine D2/D3 receptors. The interpretation of fMRI data involving opioiddopamine interactions requires careful consideration.