Hans F. Wehrl1, Martin S. Judenhofer1, Florian C. Maier1, Petros Martirosian2, Gerald Reischl3, Fritz Schick2, Bernd J. Pichler1
1Laboratory for Preclinical Imaging of the Werner Siemens-Foundation, University of Tuebingen, Tuebingen, BW, Germany; 2Section on Experimental Radiology, University of Tuebingen, Tuebingen, BW, Germany; 3Radiopharmacy and PET-Center, University of Tuebingen, Tuebingen, BW, Germany
PET/MR imaging is an emerging technology. In this study, for the first time, PET as well as MR-ASL perfusion data were acquired simultaneously with a small animal PET/MR device, therefore minimizing confounding parameters such as physiological variations between the scans. Absolute [15O]water PET and MR perfusion data were compared, and discussed in respect to blood-brain-barrier permeability issues. Permeability surface (PS) product values for different brain areas were determined. These experiment show an excellent application of PET/MR for cross-validation studies and pave the way for a wider range of multifunctional-imaging studies.