Hans F. Wehrl1,
Martin S. Judenhofer1, Florian C. Maier1, Petros
Martirosian2, Gerald Reischl3, Fritz Schick2,
Bernd J. Pichler1
1Laboratory for Preclinical Imaging of
the Werner Siemens-Foundation, University of Tuebingen, Tuebingen, BW,
Germany; 2Section on Experimental Radiology, University of
Tuebingen, Tuebingen, BW, Germany; 3Radiopharmacy and PET-Center,
University of Tuebingen, Tuebingen, BW, Germany
PET/MR
imaging is an emerging technology. In this study, for the first time, PET as
well as MR-ASL perfusion data were acquired simultaneously with a small
animal PET/MR device, therefore minimizing confounding parameters such as
physiological variations between the scans. Absolute [15O]water
PET and MR perfusion data were compared, and discussed in respect to blood-brain-barrier
permeability issues. Permeability surface (PS) product values for different
brain areas were determined. These experiment show an excellent application
of PET/MR for cross-validation studies and pave the way for a wider range of
multifunctional-imaging studies.