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Abstract #0739

Comparison of Cortical Folding Measures for Evaluation of Developing Cortex

Joshua S. Shimony1, Jason Hill1, John Harwell1, Tim Coalson1, Dierker Donna1, Terrie Inder1, David Van Essen1, Jeff J. Neil1

1Washington University in St. Louis, St. Louis, MO, United States

A variety of measures have been proposed to evaluate cortical folding, many of which are based on the mathematical quantity of curvature. We obtained MRI data from premature infants at <27, 30-31, 34-35, and 38-39 wks postmenstrual age (PMA). We evaluated how 17 cortical folding measures change with increasing PMA. There was considerable disparity in the sensitivity of the measures to cortical maturation, though a subset increased in a monotonic and predictable fashion, making them suitable for evaluation of brain development.