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Abstract #0740

Quantification of Tissues Maturation in the Infant Brain with Multi-Parametric MRI

Jessica Dubois1,2, Cyril Poupon3,4, Franois Leroy1,4, Giovanna Santoro1, Jean-Franois Mangin3,4, Lucie Hertz-Pannier2,5, Ghislaine Dehaene-Lambertz1,4

1U562, Inserm, Gif-sur-Yvette, France; 2LBIOM, CEA, Gif-sur-Yvette, France; 3LNAO, CEA, Gif-sur-Yvette, France; 4IFR49, Paris, France; 5U663, Inserm, Paris, France

Brain development proceeds with a specific spatio-temporal pattern across regions during early infancy and childhood. MRI has recently enabled to study this process non-invasively, but the functional significance of MRI indices is still controversial. Here we used multi-parametric quantitative MRI to investigate this issue in the developing brain of 10 healthy infants (age: 6 to 18weeks). Diffusion Tensor Imaging and T1-T2 mappings were performed over the whole brain in a short acquisition time with EPI sequences. The indices quantification highlighted variable age-related changes across different regions of grey and white matter, and specific relationships between indices according to maturational processes.