In Vivo Identification of a Molecular Marker for Brown Adipose Tissue in NMR Spectra of Large Volumes

Rosa Tamara Branca¹, Warren Sloan Warren²

A molecular signature of brown adipose tissue is found in the iZQC spectrum of mice. More specifically the iZQC resonance frequency line between methylene protons (-CH2-) at 1.3ppm and water, at cellular length scales, seems to be characteristic of the only BAT tissue. This method is applied in vivo to screen normal and obesity mouse models, and to track the BAT response to adrenergic stimulation and cold exposure.