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Abstract #0749

Characterization of Brown Adipose Tissue in Mice with IDEAL Fat-Water MRI

Houchun Harry Hu1, Daniel Larry Smith, Jr. 2, Michael I. Goran3, Tim R. Nagy2, Krishna S. Nayak1

1Electrical Engineering, University of Southern California, Los Angeles, CA, United States; 2Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, United States; 3Preventive Medicine, Pediatrics, Physiology & Biophysics, University of Southern California, Los Angeles, CA, United States

The fat fraction from IDEAL-MRI is used to non-invasively characterize brown adipose tissue (BAT) in mice. We first demonstrate the ability to identify various BAT depots with IDEAL. We then demonstrate with IDEAL differences in BAT between mice that were housed at 19C and 25.5C for three consecutive weeks. The interscapular BAT fat fractions in the colder animals were (35.248.6%), in contrast to the warmer animals (48.460.9%), p<0.01. The two groups exhibited similar gains in body weight, despite a significant 29% greater food intake by the 19C animals. These findings support BATs involvement in thermogenesis and lipid metabolism.