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Abstract #0753

Real-Time Assessment of in Vivo Postprandial Lipid Storage in Rat Liver Using 1H-[13C] MRS

Richard Jonkers1, Tom Geraedts1, Luc van Loon2, Klaas Nicolay1, Jeanine Prompers1

1Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Department of Human Movement Sciences, Maastricht University Medical Centre+, Maastricht

Insulin resistance and type 2 diabetes are associated with elevated liver lipid content. It remains unknown whether this excessive accumulation of triglycerides is a result of increased lipid uptake or decreased lipid oxidation. In this study, we measured for the first time postprandial lipid storage in rat liver in vivo using localized 13C-edited 1H-observed MRS and 13C labeled lipids as tracers. The 13C enrichment of the liver lipid pool was 0.9 0.7% at baseline and increased to 4.8 0.9% 5h after ingestion of the tracer, showing that we can assess changes in 13C enriched lipid content in vivo.