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Abstract #0784

Preliminary In-Vivo Bone Quantification Results Using MR and PQCT

Victor Rakesh Lazar1, Gary P. Liney2, David J. Manton1, Peter Gibbs1, Martin Lowry1, Celia L. Gregson3, Joern Rittweger4, Sue Steel5, Chris Langton6, J H. Tobias3, Lindsay W. Turnbull1

1Centre for MR Investigations, University of Hull, Hull, North Humberside, United Kingdom; 2Radiotherapy Physics, University of Hull, Hull, North Humberside, United Kingdom; 3Academic Rheumatology, University of Bristol, Bristol, United Kingdom; 4Excercise and Sports Medicine, Manchester Metropolitan University, Manchester, United Kingdom; 5Centre for Metabolic Bone Disease, Hull Royal Infirmary, Hull, North Humberside, United Kingdom; 6School of Physical and Chemical Sciences, Queensland University of Technology, Australia

Bone quantification is commonly measured using DEXA and pQCT. Research in MRI and MRS have shown promising potential in the quantification of bones. Our work was based on using these ideas in a clinical setting on individual patients. The work was involved in a High Bone Mass (HBM) study program to identify individuals affected with a genetic condition of LRP5. pQCT data was collected from 169 individuals from the HBM study. 43 people were selected for MRI and MRS acquisition from the total pQCT population. Preliminary results from these investigations have been explained in this abstract.