Victor Rakesh Lazar1, Gary P. Liney2,
David J. Manton1, Peter Gibbs1, Martin Lowry1,
Celia L. Gregson3, Joern Rittweger4, Sue Steel5,
Chris Langton6, J H. Tobias3, Lindsay W. Turnbull1
1Centre for MR Investigations,
University of Hull, Hull, North Humberside, United Kingdom; 2Radiotherapy
Physics, University of Hull, Hull, North Humberside, United Kingdom; 3Academic
Rheumatology, University of Bristol, Bristol, United Kingdom; 4Excercise
and Sports Medicine, Manchester Metropolitan University, Manchester, United
Kingdom; 5Centre for Metabolic Bone Disease, Hull Royal Infirmary,
Hull, United Kingdom; 6School of Physical and Chemical Sciences,
Queensland University of Technology, Australia
Peripheral
Quantitative Computed Tomography (pQCT) and Dual Energy X-Ray Absorptiometry
(DEXA) are the current gold standards for the measurement of bone density and
structure, in the research and clinical setting respectively. However,
Magnetic Resonance Imaging (MRI) and unsuppressed 1H Magnetic Resonance
Spectroscopy (MRS) can also offer several advantages including the ability to
quantify bone marrow content and structure. In-house software was developed
to process and evaluate cortical and trabecular bone structure, marrow
composition and vertebrae segmentation using data from MRI/MRS and structural
details from pQCT.