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Abstract #0794

The Effect of Freezing on Measurements of Trabecular Bone Structure Based on NMR Spectroscopy

Viktoria Prantner1, Hanna Isaksson1, Johanna Nrvinen2, Eveliina Lammentausta3, Olli HJ Grhn2,4, Jukka S. Jurvelin1

1Department of Physics, University of Kuopio, Kuopio, Finland; 2A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland; 3Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 4Biomedical Imaging Unit, University of Kuopio, Kuopio, Finland

NMR is a potential tool for the assessment of trabecular bone structure. Since trabecular bone provides a negligible NMR signal, the indirect evaluation of the trabecular bone structure is based on the analysis of water and fat components in the bone marrow. Earlier studies have revealed that freezing affects the bone marrow structure, suggesting there may be changes in the molecular structure. The aim of the current study is to investigate the effect of freezing on trabecular bone and bone marrow, as assessed by NMR spectroscopy.