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Abstract #0795

Performance of Two Spin-Echo Sequences for Quantitative Structure Analysis of Trabecular Bone

Michael Jeffrey Wald1, Jeremy Francis Magland1, X. Edward Guo2, Felix Werner Wehrli1

1Laboratory for Structural NMR Imaging, University of Pennsylvania Medical Center, Philadelphia, PA, United States; 2Bone Bioengineering Laboratory, Columbia University, New York, United States

The performance of two spin-echo based pulse sequences for imaging trabecular bone microstructure are evaluated at 1.5T in seven fixed, cadaveric distal tibia specimens. SNR efficiency and sensitivity of image-derived trabecular bone structural parameters to variations in bone quality as assessed by CT were investigated. Inter- pulse sequence correlations suggest similar structural sensitivity, while comparisons to CT reveal good sensitivity but large deviations in absolute values between modalities.