Michael Jeffrey Wald1, Jeremy Francis Magland1, X. Edward Guo2, Felix Werner Wehrli1
1Laboratory for Structural NMR Imaging, University of Pennsylvania Medical Center, Philadelphia, PA, United States; 2Bone Bioengineering Laboratory, Columbia University, New York, United States
The performance of two spin-echo based pulse sequences for imaging trabecular bone microstructure are evaluated at 1.5T in seven fixed, cadaveric distal tibia specimens. SNR efficiency and sensitivity of image-derived trabecular bone structural parameters to variations in bone quality as assessed by CT were investigated. Inter- pulse sequence correlations suggest similar structural sensitivity, while comparisons to CT reveal good sensitivity but large deviations in absolute values between modalities.