Laura Mancini1,2, Rathie Rajendram3,
Jimmy Uddin3, Richard W J Lee4, Geoffrey E. Rose3,
Tarek Yousry1,2, Katherine Miszkiel1,3, John S.
Thornton1,2
1Lysholm Dept Neuro-radiology, National
Hospital for Neurology and Neurosurgery, Univ College London Hospitals NHS
Foundation Trust, London, United Kingdom; 2Academic
Neuroradiological Unit, Institute of Neurology, University College of London,
London, United Kingdom; 3Moorfields Eye Hospital NHS Foundation
Trust, London, United Kingdom; 4Academic Unit of Ophthalmology,
Clinical Science at South Bristol, University of Bristol, Bristol, United
Kingdom
This
study shows that there is correlation between T2 relaxation values in the
extra-orbital muscles of patients with thyroid eye disease and Clinical
Activity Score (CAS). CAS is the gold-standard measure of disease activity,
considered to reflect the degree of orbital inflammation, while T2-weighted
images are sensitive to changes in tissue water content concomitant with
extra-orbital muscle inflammation. This study represents a validation of T2
measurements as outcome measures for studies of interventions in TED. T2
measures have therefore the potential to improve the quality of data reported
in Randomised Control Trials.
Keywords